MLB Picks 4/21/22
There are a lot of great MLB games featured in our MLB Picks. Today’s biggest game features the San Francisco Giants vs New York Mets. I am on the San Francisco Giants +124 in this game. One underdog to watch on this card is the St. Louis Cardinals +115. Another team to pay attention to on this card is the Oakland Athletics -125. What do you think of today’s games?
Top Plays
- Oakland Athletics -125
- Seattle Mariners -137
Card

Computer Picks
Game | Pick | Start Time(EST) |
---|---|---|
Cleveland Guardians vs Chicago White Sox | Chicago White Sox -137 | 1:10 PM |
San Francisco Giants vs New York Mets | San Francisco Giants +124 | 1:10 PM |
New York Yankees vs Detroit Tigers | New York Yankees -155 | 1:11 PM |
Toronto Blue Jays vs Boston Red Sox | Toronto Blue Jays -115 | 1:36 PM |
Minnesota Twins vs Kansas City Royals | Minnesota Twins -114 | 2:10 PM |
Oakland Athletics vs Baltimore Orioles | Oakland Athletics -125 | 3:37 PM |
Washington Nationals vs Arizona Diamondbacks | Washington Nationals -123 | 4:05 PM |
St. Louis Cardinals vs Miami Marlins | St. Louis Cardinals +115 | 6:41 PM |
Pittsburgh Pirates vs Chicago Cubs | Chicago Cubs -133 | 7:40 PM |
Texas Rangers vs Seattle Mariners | Seattle Mariners -137 | 9:41 PM |
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